Aspirin is linked with increased risk of heart failure

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The use of aspirin is associated with a 26% increased risk of heart failure in people who have at least one predisposition to this condition.It’s the discovery of the research published today ESC heart failure, Journal of the European Society of Cardiology (ESC). Predisposition included smoking, obesity, high blood pressure, high cholesterol, diabetes, and cardiovascular disease.

“This is among individuals with at least one risk factor. heart failure, Who is taking aspirin Dr. Brelim Mujazi, a research author at the University of Freiburg, Germany, said, “This finding needs confirmation, but with aspirin. heart We need to clarify our mistakes. “

The effects of aspirin on heart failure are controversial. The purpose of this study is to evaluate the relationship between the incidence of heart failure in people with and without heart disease and whether the use of this drug is associated with a new diagnosis of heart failure in people at risk. increase.

The analysis included 30,827 individuals at risk of developing heart failure enrolled in the HOMAGE study from Western Europe and the United States. “At risk” means smoking, obesity, High blood pressure, High cholesterol, diabetes, cardiovascular disease. Participants were over 40 years old and had no heart failure at baseline. Use of aspirin was recorded at registration and participants were classified as users or non-users. Participants were followed up on the initial incidence of fatal or non-fatal heart failure requiring hospitalization.

The average age of participants was 67, with 34% being female. At baseline, a total of 7,698 participants (25%) were taking aspirin. During the 5.3-year follow-up period, 1,330 participants developed heart failure.

Researchers have adjusted aspirin use and accidental treatment with gender, age, weight index, smoking, alcohol use, blood pressure, heart rate, blood cholesterol, creatinine, hypertension, diabetes, cardiovascular disease, and renin. Assessed association with heart failure-angiotensin-aldosterone inhibitor, Calcium channel blocker, Diuretics, beta blockers, lipid lowering agents. Taking aspirin was independently associated with a 26% increased risk of new heart failure diagnoses.

To confirm the consistency of the results, the researchers compared aspirin users and non-users for heart failure and then repeated the analysis. Risk factor.. In this consistent analysis, aspirin increased the risk of new heart failure diagnoses by 26%. To further confirm the results, the analysis was repeated after excluding patients with a history of cardiovascular disease. Free for 22,690 participants (74%) Cardiovascular disease, Aspirin use was associated with a 27% increased risk of accidental heart failure.

“This was the first major study to investigate the relationship between the use of aspirin and the development of heart failure,” said Dr. Mujaji. Heart disease And at least one risk factor. Aspirin is commonly used — in our study, one in four participants was taking the drug. In this population, use of aspirin was associated with accidental heart failure, independent of other risk factors. “

“To verify these results, we need a large multinational randomized trial of adults at risk for heart failure. Until then, there are people with heart failure or risk factors for heart failure. It suggests that people need to be carefully prescribed aspirin. ”

For more information:

Mujaj B, Zhang ZY, Yang WY, et al.. Use of aspirin is associated with an increased risk of accidental heart failure: patient-level pool analysis. ESC Heart Fail.. 2021. DOI: 10.1002 / ehf2.13688..

Quote: Aspirin is an increased risk of heart failure obtained from on 22 November 2021 (22 November 2021) ) Is related

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