People who have been vaccinated with Johnson & Johnson’s COVID-19 vaccine may benefit from a booster dose of Pfizer or Moderna, preliminary results from a US study published Wednesday show.
The study, funded by the National Institutes of Health (NIH), was long-awaited in the United States as it examined the possibility of “mixed” vaccines using vaccines that differed from the initial dose of the vaccine. amplifier Shot — Currently not allowed in the country.
The study was conducted on 458 adults who were vaccinated with any of the three US-approved brands (Pfizer, Modana, or J & J) for at least 12 weeks.
These three groups were each divided into three new groups to receive one of the vaccines available as a booster. Each of the nine groups consisted of about 50 people.
The researchers then analyzed antibody levels 15 days after the booster shot.
For those who were originally inoculated with J & J, antibody levels were 4 times higher after the J & J booster, 35 times higher after the Pfizer booster, and 76 times higher after the Moderna booster.
When Antibody level Studies show that those who received the first moderna shot were higher “regardless of the booster vaccine given” than those who received the first Pfizer or J & J.
In addition, it was found that “no safety concerns were identified” after booster immunization.
However, this study, which has not yet been peer-reviewed, has some limitations.
The number of participants is small, Immune response It can evolve over time beyond the 15 days observed during the study.
“It’s important not to get too absorbed in the findings,” said Peter Hotez, a professor at Baylor College of Medicine.
Results of the second J & J test Booster shot He said what the company itself did was “impressive.”
The NIH study should facilitate discussions by the US Food and Drug Administration (FDA) expert committee. The committee will consider applying for booster doses from Moderna and J & J on Thursday and Friday, respectively.
Pfizer boosters have already been approved in the United States for certain populations, including people over the age of 65, adults with high-risk medical conditions, and people with jobs that are frequently exposed to the coronavirus.
© 2021 AFP
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