At initial cancer diagnosis, a deeply personalized assessment can help guide treatment plan

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In the treatment of cancer, personalized medicine means recognizing that the same disease can behave differently from patient to patient, and precision medicine means tumors and diseases of each patient in diagnosis and treatment. This means that it is necessary to include understanding the specific genetic makeup of.

A recent study was published on October 4, 2021. Genome medicineResearchers at the Moores Cancer Center at the University of California, San Diego Medical College and the University of California, San Diego Health, along with other colleagues, performed a genomic assessment of advanced malignancies, standard treatment failed.

By their nature, cancers are molecularly complex, each with a heterogeneous combination of genetic mutations, often opposed to simple treatment. At all stages and lines of treatment, Tumor cells Adapt to become more resistant to treatment.

The authors of the study hypothesized that it may be feasible and effective to develop consistent, individualized combination therapies for patients with advanced cancer who have not been previously treated.

A little less than 150 adults newly diagnosed with malignancies were enrolled in a prospective study at two facilities, the Moores Cancer Center and the Avella Cancer Institute in Sioux Falls, South Dakota. Patients had incurable fatal cancer (at least 50% cancer-related mortality within 2 years) or had rare tumors for which there was no approved treatment.

Researchers have performed extensive genomic profiling of all patients, identified and documented all detectable genetic mutations, and created molecular profiles of each patient’s tumor to guide accurate cancer treatment.

“Each patient received an optimally matched personalized N-of-1 treatment plan. Therapeutic In addition to the clear biology of the tumor, taking into account other variables such as the underlying disease and its patient-specific comorbidities, “said Jason Sickrick, a professor of surgery and surgical oncology at the University of California, San Diego School of Medicine. The doctor of medicine said. Moore Cancer Center.

Of the 145 patients, 76 received personalized treatment based on their molecular profile, using many therapeutic approaches, from immunotherapy to targeted agents to traditional chemotherapeutic agents that match the genomic profile of the tumor. I did. 69 patients could not be treated for a variety of reasons, including inadequate organ function, clinical deterioration and death during the study period.

For 76 patients who received accuracy cancer TreatmentThe median overall survival was 6.9 months compared to 3 months for untreated patients.

“This speaks to the aggressive biology of these cancers. Many of these patients Precision medicine “Molecular profiling (tissue and blood) failure affected only 3 (2%) of agreed patients, suggesting that it was possible to perform molecular profiling in 98% of patients. “The authors said.

Findings conclude researchers and confirm precisely personalized beliefs medicineThe benefits of targeting multiple drivers of illness, rather than a single cause.

“It also shows that it is possible to move this approach early in the treatment process for lethal malignancies with the goal of improving outcomes before resistance mutations accumulate,” they write. rice field.

For more information:

Jason K. Sicklick et al, Molecular Profiling of Advanced Malignancies, Guides Primary N-of-1 Treatment in Inexperienced I-PREDICT Treatment Studies. Genome medicine (2021). DOI: 10.1186 / s13073-021-00969-w

Quote: In the first cancer diagnosis, a deeply personalized assessment was obtained from on October 13, 2021. Useful for your guide (October 13, 2021). html

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